Neomycin Sulfate Soluble Powder

Veterinary drug name

 Generic Name：Neomycin Sulfate Soluble Powder

 Trade Name：
Chinese name：硫酸新霉素可溶性粉
Chinese Pinyin：Liusuan Xinmeisu Kerongxingfen
Content specifications:  100g: 32.5g (32.5million IU)
Packing:500g × 20 bags / carton

Active Ingredient: Neomycin sulfate

Description: white to light yellow powder

Pharmacodynamics: Neomycin is an aminoglycoside antibiotics which is similar to kanamycin. It is very effective against most Gram-negative bacteria such as E. coli, Proteus, Salmonella, and Pasteurella multocida. It is also sensitive to Staphylococcus but drug resistance for Pseudomonas, Gram positive bacteria (except Staphylococcus), Rickettsia, anaerobic bacteria, and fungus. 

Pharmacokinetics: Neomycin whether used in feed or external use has very little amount absorbed. After administrated orally, only 3% of total dosage discharged from urine, and the rest is in feces. Inflammation of the intestinal mucosa or ulcer may increase the absorption. Administrate through injection can be absorbed quickly and with the same process as kanamycin.

Drug Interaction: 

1.Usage with macrolide antibiotics can treat mastitis caused by Gram-negative bacteria. 

2.Administrate orally will affect the absorption of digitalis drugs, vitamin A, and vitamin B12.

3.Addition of penicillin or cephalosporins together can have a better effect.

4.The drug is used best in basic environment, and with the help of basic chemicals (sodium bicarbonate and aminophylline), the effect will increase greatly but so will the toxicity. When the pH value is over 8.4, the antibacterial activity decreases.

5.Ca ²⁺、Mg ²⁺、Na ⁺、NH  ⁺, and K ⁺ can inhibit the antibacterial activity of the product.

6.Addition of cephalosporin, dextran, strong diuretics (Furosemide), erythromycin together can increase the neomycin’s ototoxicity.

7.Skeletal muscle relaxants (suxamethonium chloride) or this kind of medicine can increase neomycin sulfate’s neuromuscular blockade reaction. 

Indications: macrolide antibiotics. In treatment for bacterial infections in gastrointestinal tract by Gram-negative bacteria. 

Administration and Dosage: oral use. Poultry: 0.15~0.22g/l for 3~5 days.

Contraindications: Neomycin is the most toxic of all macrolide antibiotics but administrated orally or externally present few poison reactions.

Precaution: 1. Do not use on layers during laying.

2. the drug will affect the absorption of digitalis drugs, vitamin A, and vitamin B12.

Withdrawal Time:  chicken: 5 days; turkey :14 days

Storage: store in a tightly sealed container and keep in a dry place.